![]() Because of the low acute toxicity and apparent lack of interaction, DMSO is a useful solvent for studying the effects of pesticides in animals. The depression was abolished by dilution. Undiluted DMSO produced a depression of spontaneous motor activity without an effect on hexobarbital sleeping time or the conditioned avoidance response. For many substances, such as covalently bound liquids, it's useful to know the polarity of an entire molecule rather than its individual bonds. It is measured in 0 to 11 debyes (D), with 0 indicating no dipole moment and 11 being strongly polar. Some differences in the times of the onset of signs of toxicity were noted. Measuring Polarity Bond dipole moment is the measure of the polarity of a chemical bond. The acute oral toxicities of thiram, dieldrin, carbaryl, MC-A-600, and parathion were generally similar whether administered in DMSO, in corn oil, or as an aqueous suspension. Some significant differences in the inhibition of cholinesterase by carbaryl in the various solvents were observed. None of these solvents influenced brain cholinesterase activity. A delayed toxicity was noted with DMSO, DMA, DMF, and PG by each route. The toxicities of DMSO and DMF were unchanged by dilution with water. The results indicate that DMSO is less toxic than DMA and DMF. ![]() The acute oral and intraperitoneal toxicities of dimethyl sulfoxide (DMSO), dimethyl acetamide (DMA), dimethyl formamide (DMF), and propylene glycol (PG), diluted and undiluted, were compared in rats after 24-hour and 5-day periods. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |